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ALCOHOLISM TEST BACKS THE DISEASE IDEA:Zusammenfassung - Über Punyamurtula S. Kishore, MD, MPH, FASAM Team Members: Punyamurtula Kishore Zusammenfassung Über Punyamurtula S. Kishore, MD, MPH, FASAM Dr. Kishore begann seine medizinische Karriere als praktischer Arzt und zog dann in eine Position als Acting medizinischer Direktor des Washingtonian Center für Süchte, die erste Organisation in den USA sucht als Krankheit zu erkennen. Ihre Philosophie war ein früher Vorläufer der Anonymen Alkoholiker oder 12-Schritte-Programm movement(http://silkworth.net/washingtonians/washingtonian_movement_comparison_aa.html). Seit 1989 hat Dr. Kishore süchtig mehr als 200.000 Personen und ihrer Familienangehörigen durch seinen Zustand Breite Praktiken in Massachusetts behandelt. Seit 1987 ist er Mitglied der amerikanischen Gesellschaft für Suchtmedizin (http://www.asam.org/). Im Jahr 2010 wurde Dr. Kishore Fellow der Society. Amerikanische Gesellschaft der Suchtmedizin und der ASAM-Verwaltungsrat erkennt diese Elite Professionals für besondere Anerkennung als "Fellows" aufgrund ihrer bedeutenden Beiträge auf dem Gebiet der Suchtmedizin und Arbeit als herausragende, Prominente und angesehenen Experten in der medizinischen Gemeinschaft. Diese Fachleute haben "eindeutig" für besondere Auszeichnung von einer geschätzten 1,5 Millionen Ärzte ausgesondert worden. Er hält seinen Master-Abschluss im Gesundheitswesen aus Harvard School of Public Health (http://www.hsph.harvard.edu/). Er erhielt seinen medizinischen Abschluss an der Andhra University in Indien. Dr. Kishore hält auch Zertifikate in forensische Psychologie von Bridgewater State College. Er wurde geehrt durch die Boston Celtics durch die "Heroes Among Us" Auszeichnung für Personen, die einen überwältigenden Einfluss auf ihre Gemeinden gemacht haben.(http://www.nba.com/celtics/community/heroes_2004_11.html). Dr. Kishore ist auch der Empfänger eine mitfühlende Caregiver Staatspreis, lobende Erwähnung, der Schwartz-Stiftung. Er ist Gründer und geschäftsführender Direktor der nationalen Bibliothek von Neigungen in Brookline less Alcoholism Test Backs Disease Idea(Click/Tap here for Expanded View) Team Members: Punyamurtula Kishore, David D. Rutstein Evidence of a chemical abnormality in the way severe alcoholics metabolize alcohol has been discovered by scientists at Harvard and two Federal research centers. The finding strengthens the evidence that alcoholism is a disease rather than a social phenomenon, according to Dr. David D. Rutstein of Harvard Medical School, one of the leaders of the research.

uf813 By HAROLD M. SCHMECK Jr. Evidence of a chemical abnormality in the way severe alcoholics metabolize alcohol has been discovered by scientists at Harvard and two Federal research centers. The finding strengthens the evidence that alcoholism is a disease rather than a social phenomenon, according to Dr. David D. Rutstein of Harvard Medical School, one of the leaders of the research. Furthermore, he and his colleagues hope it may lead to an early test for predispositon to alcoholism that might be valuable to warn those who might be afflicted. The scientists have found, in the blood of males suffering from severe alcholism, a substance that appears not to be produced by nonalcoholics in their metabolic disposal of alcohol. Furthermore the substance in the alcoholics' blood did not appear to reflect liver damage or any of the other known biological effects of prolonged severe alcoholism, Dr. Rutstein said. Metabolic Difference Posited The scientific team believes production of the substance, called 2,3-butanediol, probably reflects an intrinsic metabolic difference between severe alcoholics and nonalcoholics. Further research is being pursued. Other chemical abnormalities in alcoholics have been suggested in the past in research, but the subject continues to be a subject of scientific controversy. The discovery followed research with rats in which chemical treatment of the animals blocked the normal sequence of biochemical steps in their metabolism of alcohol. Under this circustance, the animals evidently switched to another sequence of chemical steps to use and dispose of the alcohol and produced 2,3-butanediol in the course of this. The leader in this chemical aspects of the research was Dr. Richard L. Veech of the National Institute on Alcohol Abuse and Alcoholism in Rockville, Md. The substance is naturally found as a fermentation product in wine and beer, but not in such distilled alcohol products as whisky, gin and vodka. Nevertheless it was found in the blood of severe alcoholics after drinking only distilled alcohol products. Study Furthered at Party The finding that male alcoholics did produce the chemical was followed by a controlled study to see if comparable amounts of the same substance could be found in the blood of nonalcoholics after thay had been drinking. To determine this, Dr. Rutsteins said, the scientists tested the blood of a group of nonalcoholics, most of them Harvard faculty members who were invited to a party at which the price of admission was willingness to give blood samples before and afterward. Unlike the alcoholics, their blood showed no buildup of the chemical after drinking. Those who drank wine or beer at the party were excluded from the study. A report of the research is published in the latest issue of The Lancet, an international medical journal. The authors, in addition to Drs. Rutstein and Veech are Rita J. Nickerson and Punyamurtula Kishore of Harvard; Michael E. Felver of the institute and Drs. Andrew A. Vernon, Larry L. Needham and Stephen B. Thacker of the Centers for Disease Control, a Federal facility in Alanta. On the basis of the evidence from the controlled study of 19 severe alcoholics compared with 22 normal males, the scientists said, they hypothesized ''that in the alcoholic male patient, ethanol (alcohol) is metabolized along a different pathway, with different pathway controls, or with different metbolic effects than it is in the nonalcoholic.''